筑波大学 体育系 スポーツ医学
前田・小﨑研究室
Maeda / Kosaki Laboratory

《2006年の論文》


(1) Iemitsu M, Maeda S, Takeshi Otsuki, Katsutoshi Goto, Takashi Miyauchi. Time course alterations of myocardial endothelin-1 production during the formation of exercise training-induced cardiac hypertrophy. Exp Biol Med. 231: 871-875, 2006.

(2) Masuzawa K, Goto K, Jesmin S, Maeda S, Miyauchi T, Kaji Y, Oshika T, Hori S. An endothelin type A receptor antagonist reverses upregulated VEGF and ICAM-1 levels in streptozotocin-induced diabetic rat retina. Curr Eye Res. 31: 79-89, 2006.

(3) Shimojo N, Jesmin S, Zaedi S, Soma M, Kobayashi T, Maeda S, Yamaguchi I, Goto K, Miyauchi T. EPA effect on NOS gene expression and on NO level in endothelin-1–induced hypertrophied cardiomyocytes. Exp Biol Med. 231: 913-918, 2006.

(4) Jesmin S, Zaedi S, Yamaguchi N, Maeda S, Yamaguchi I, Goto K, Miyauchi T. Effects of dual endothelin receptor antagonist on antiapoptotic marker Bcl-2 expression in streptozotocin-induced diabetic rats. Exp Biol Med. 231: 1034-1039, 2006.

(5) Otsuki T, Maeda S, Kesen Y, Yokoyama N, Tanabe T, Sugawara J, Miyauchi T, Kuno S, Ajisaka R, Matsuda M. Age-related reduction of systemic arterial compliance induces excessive myocardial oxygen consumption during sub-maximal exercise. Hypertens Res. 29: 65-73, 2006.

(6) Shimojo N, Jesmin S, Zaedi S, Soma M, Kobayashi T, Maeda S, Yamaguchi I, Goto K, Miyauchi T. Effect of eicosapentaenoic acid on the different endothelin system components in endothelin-1–induced hypertrophied cardiomyocytes. Exp Biol Med. 231: 888-892, 2006.

(7) Iemitsu M, Maeda S, Miyauchi T, Kuno S, Murakami K, Matsuda M. Gene expression profiling of exercise training-induced cardiovascular adaptations: molecular insight from microarray analyses. Int J Sport Health Sci. 4: 451-459, 2006.

(8) Zaedi S, Jesmin S, Yamaguchi N, Shimojo N, Maeda S, Gando S, Yamaguchi I, Goto K, Miyauchi T. Altered expression of endothelin, vascular endothelial growth factor, and its receptor in hepatic tissue in endotoxemic rat. Exp Biol Med. 231: 1182-1186, 2006.

(9) Sugawara J, Otsuki T, Tanabe T, Takahashi K, Yamasaki K, Hayashi K, Yoshino K, Matsuoka K, Arai K, Maeda S, Kuno S, Ajisaka R, Matsuda M. Association between the ventilatory threshold and the break-point in the heart rate/work rate relationship: comparison with the break-point in the double product/work rate. Int J Sport Health Sci. 4: 499-507, 2006.

(10) Masuzawa K, Jesmin S, Maeda S, Kaji Y, Oshika T, Zaedi S, Shimojo N, Yaji N, Miyauchi T, Goto K. A model of retinal ischemia-reperfusion injury in rats by subconjunctival injection of endothelin-1. Exp Biol Med. 231: 1085-1089, 2006.

(11) Tanabe T, Maeda S, Sugawara J, Otsuki T, Kuno S, Ajisaka R, Matsuda M. Effect of daily physical activity on systemic arterial compliance in middle-aged and elderly humans: special references in amount and intensity of physical activity. Int J Sport Health Sci. 4: 489-498, 2006.

(12) Otsuki T, Maeda S, Iemitsu M, Saito Y, Tanimura Y, Ajisaka R, Goto K, Miyauchi T. Effects of athletic strength and endurance exercise training in young humans on plasma endothelin-1 concentration and arterial distensibility. Exp Biol Med. 231: 789-793, 2006.

(13) Sugawara J, Otsuki T, Tanabe T, Hayashi H, Maeda S, Kuno S, Ajisaka R, Matsuda M. The effects of daily physical activity on the age-related carotid arteria stiffening in middle-aged and elderly people. J Phys Fitness Sports Med. 55: S11-S14, 2006.

(14) Masuzawa K, Jesmin S, Maeda S, Zaedi S, Shimojo N, Miyauchi T, Goto K. Effect of endothelin dual receptor antagonist on VEGF levels in streptozotocin-induced diabetic rat retina. Exp Biol Med. 231: 1090-1094, 2006.

(15) Jesmin S, Hattori Y, Maeda S, Zaedi S, Sakuma I, Miyauchi T. The subdepressor dose of benidipine ameliorates diabetic cardiac remodeling accompanied by the normalization of the upregulated endothelin system in rats. Am J Physiol Heart Circ Physiol. 290: H2146-H2154, 2006.

(16) Shimojo N, Jesmin S, Zaedi S, Maeda S, Gando S, Yamaguchi I, Goto K, Miyauchi T. Alterations of gene expressions of preproET-1 and ET receptors in brain of endotoxemic Sprague-Dawley rat. Exp Biol Med. 231: 1058-1063, 2006.

(17) Iemitsu M, Maeda S, Jesmin S, Otsuki T, Kasuya Y, Miyauchi T. Activation pattern of MAPK signaling in the hearts of trained and untrained rats following a single bout of exercise. J App Physiol.101: 151-163, 2006.

(18) Shimojo N, Jesmin S, Zaedi S, Maeda S, Soma M, Aonuma K, Yamaguchi I, Miyauchi T. Eicosapentaenoic acid prevents endothelin-1-induced cardiomyocyte hypertrophy in vitro through the suppression of TGF-ß1 and phosphorylated JNK. Am J Physiol Heart Circ Physiol. 291: H835-H845, 2006.

(19) Zaedi S, Jesmin S, Maeda S, Shimojo N, Yamaguchi I, Goto K, Miyauchi T. Alterations in gene expressions encoding preproET-1 and NOS in pulmonary tissue in endotoxemic rats. Exp Biol Med. 231: 992-996, 2006.

(20) Iemitsu M, Maeda S, Otsuki T, Sugawara J, Tanabe T, Kuno S, Ajisaka R, Miyauchi T, Matsuda M. Polymorphism in endothelin-related genes limits exercise-induced decreases in arterial stiffness in the older subjects. Hypertension. 47: 928-936, 2006.

(21) Jesmin S, Zaedi S, Maeda S, Mowa CN, Sakuma I, Miyauchi T. Reversal of elevated cardiac expression of TGFß1 and endothelin-1 in OLETF diabetic rats by long-acting calcium antagonist. Exp Biol Med. 231: 907-912, 2006.

(22) Iemitsu M, Maeda S, Jesmin S, Otsuki T, Miyauchi T. Exercise training improves aging-induced downregulation of VEGF angiogenic signaling cascade in the heart. Am J Physiol Heart Circ Physiol. 291: H1290-H1298, 2006.

(23) Shimojo N, Jesmin S, Zaedi S, Soma M, Maeda S, Yamaguchi I, Goto K, Miyauchi T. Changes in important apoptosis-related molecules in the endothelin-1-induced hypertrophied cardiomyocytes: effect of the pretreatment with eicosapentaenoic acid. Exp Biol Med. 231: 932-936, 2006.

(24) Sugawara J, Otsuki T, Tanabe T, Hayashi K, Maeda S, Matsuda M. Physical activity duration, intensity, and arterial stiffening in postmenopausal women. Am J Hypertens. 19: 1032-1036, 2006.

(25) Jesmin S, Zaedi S, Maeda S, Yamaguchi I, Goto K, Miyauchi T. Effects of a selective endothelin A receptor antagonist on the expressions of iNOS and eNOS in the heart of early streptozotocin-induced diabetic rats. Exp Biol Med. 231: 925-931, 2006.

(26) Yamaguchi N, Jesmin S, Zaedi S, Shimojo N, Maeda S, Gando S, Koyama A, Miyauchi T. Time-dependent expression of renal vaso-regulatory molecules in LPS-induced endotoxemia in rat. Peptides. 27: 2258-2270, 2006.

(27) Maeda S, Subrina Jesmin, Motoyuki Iemitsu, Takeshi Otsuki, Tomoaki Matsuo, Kazunori Ohkawara, Yoshio Nakata, Kiyoji Tanaka, Katsutoshi Goto, Takashi Miyauchi. Weight loss reduces plasma endothelin-1 concentration in obese men. Exp Biol Med. 231: 1044-1047, 2006.

(28) Otsuki T, Maeda S, Iemitsu M, Saito Y, Tanimura Y, Ajisaka R, Miyauchi T. Contribution of systemic arterial compliance and systemic vascular resistance to effective arterial elastance changes during exercise in humans. Acta Physiol.188: 15-20, 2006.

(29) Jesmin S, Zaedi S, Maeda S, Togashi H, Yamaguchi I, Goto K, Miyauchi T. Endothelin antagonism suppresses plasma and cardiac endothelin-1 levels in SHRSPs at the typical hypertensive stage. Exp Biol Med. 231: 919-924, 2006.

(30) Otsuki T, Maeda S, Iemitsu M, Jesmin S, Miyauchi T. Basal gene expression of vascular endothelial growth factor-related transcriptional factors in rat skeletal muscle differs between slow and fast fiber types. J Phys Fitness Sports Med. 55: S65-S70, 2006.

(31) Jesmin S, Zaedi S, Yamaguchi N, Maeda S, Shimojo N, Masuzawa K, Yamaguchi I, Goto K, Miyauchi T. Differential effects of selective endothelin type A receptor antagonist on the gene expression of vascular endothelial growth factor and its receptors in streptozotocin-induced diabetic heart. Exp Biol Med. 231: 902-906, 2006.

(32) Otsuki T, Maeda S, Sugawara J, Kesen Y, Murakami H, Tanabe T, Miyauchi T, Kuno S, Ajisaka R, Matsuda M. Age-related reduction of systemic arterial compliance relates to decreased aerobic capacity during sub-maximal exercise. Hypertens Res. 29: 759-765, 2006.

(33) Maeda S, Otsuki T, Iemitsu M, Kamioka M, Sugawara J, Kuno S, Ajisaka R, Tanaka H. Effects of leg resistance training on arterial function in older men. Br J Sports Med. 40: 867-869, 2006.

(34) Maeda S, Murakami H, Kuno S, Matsuda M, Murakami K. Individual variations in exercise training-induced physiological effects and genetic factors. Int J Sport Health Sci. 4: 339-347, 2006.

(35) 前田清司,大槻毅,家光素行,上岡方士,村上晴香,サブリナ・ジェスミン,久野譜也,鯵坂隆一,宮内卓. 中高齢者の筋力トレーニングと動脈スティフネスの関連 —筋力トレーニングによる健康増進の試み—. 健康医科学 21: 98-106, 2006.

(36) 鰺坂隆一,大槻毅,前田清司,松田光生,久野譜也,田中喜代次,曽根博仁. 中高齢者における血清高感度CRP濃度と運動耐容能の関連. 日本臨床スポーツ医学会誌 14: 303-310, 2006.

(37) 斉藤陽子,大槻毅,家光素行,前田清司,鰺坂隆一. 間欠的掌握運動後の筋出力回復動態の性差と筋酸素化動態との関連. 体力科学 55: 433-442, 2006.

(38) 前田清司. 身体運動と心血管系機能. 学術の動向 10: 36-41, 2006.

《2005年の論文》


(1) Kakiyama T, Sugawara J, Murakami H, Maeda S, Kuno S, Matsuda M. Effects of short-term endurance training on aortic distensibility in young males. Med Sci Sports Exerc. 37: 267-271, 2005.

(2) Sugawara J, Otsuki T, Maeda S, Tanabe T, Kuno S, Ajisaka R, Matsuda M. Effect of arterial lumen enlargement on carotid arterial compliance in normotensive postmenopausal women. Hypertens Res. 28: 323-329, 2005.

(3) Hayashi K, Sugawara J, Komine H, Maeda S, Yokoi T. Effects of aerobic exercise training on stiffness of central and peripheral arteries in middle-aged sedentary men. Jpn J Physiol. 55: 235-239, 2005.

(4) Maeda S, Iemitsu M, Jesmin S, Miyauchi T. Acute exercise causes an enhancement of tissue renin-angiotensin system in the kidney in rats. Acta Physiol Scand. 185: 79-86, 2005.

(5) Maeda S, Iemitsu M, Miyauchi T, Kuno S, Matsuda M, Tanaka H. Aortic stiffness and aerobic exercise: mechanistic insight from microarray analyses. Med Sci Sports Exerc. 37: 1710-1716, 2005.

(6) Iemitsu M, Maeda S, Miyauchi T, Matsuda M, Tanaka H. Gene expression profiling of exercise-induced cardiac hypertrophy in rats. Acta Physiol Scand. 185: 259-270, 2005.

(7) 大槻毅,気仙有実子,村上晴香,田辺匠,前田清司,久野譜也,鰺坂隆一,松田光生. 70歳以上の高齢者における低強度の有酸素性トレーニングが動脈系コンプライアンスに及ぼす影響. 日本臨床スポーツ医学会誌13: 105-109, 2005.

(8) 鰺坂隆一,大森肇,久野譜也,渡辺重行,山口巌,勝田茂,安田俊広,川島紫乃,大槻毅,前田清司,松田光生. 後期高齢者の運動負荷 −安全性および運動耐性−. 心臓 37: 48-59, 2005.

(9) 前田清司,宮内卓,後藤勝年.エンドセリンとエンドセリン拮抗薬. 血管 28: 121-132, 2005.

(10) 前田清司,宮内卓.高血圧と血管内彼障害. 糖尿病 48: 829-831, 2005.

(11) 前田清司.トレーニングに対する血管応答. 体育の科学 55: 907-912, 2005.

(12) 家光素行,前田清司,宮内卓.運動トレーニングによる心臓の適応機序:遺伝子レベルから. 筑波大学体育科学系紀要 28: 31-41, 2005.

《2004年の論文》


(1) Miyauchi T, Fujimori A, Maeda S, Iemitsu M, Sakai S, Shikama H, Tanabe T, Matsuda M, Goto K, Yamaguchi I. Chronic administration of an endothelin-A receptor antagonist improves exercise capacity in rats with myocardial infarction-induced congestive heart failure. J Cardiovasc Pharmacol. 44: S64-S67, 2004.

(2) Maeda S, Miyauchi T, Iemitsu M, Tanabe T, Goto K, Yamaguchi I, Matsuda M. Endothelin receptor antagonist reverses decreased NO system in the kidney in vivo during exercise. Am J Physiol Endocrinol Metab. 286: E609-E614, 2004.

(3) Maeda S, Iemitsu M, Miyauchi T, Goto K. Exercise-induced tissue-specific change in gene expression of endothelin-1. J Cardiovasc Pharmacol. 44: S336-S340, 2004.

(4) Iemitsu M, Miyauchi T, Maeda S, Tanabe T, Takanashi M, Matsuda M, Yamaguchi I. Exercise training improves cardiac function-related gene levels through thyroid hormone receptor signaling in aged rats. Am J Physiol Heart Circ Physiol. 286: H1696-H1705, 2004.

(5) Shimojo N, Miyauchi T, Iemitsu M, Irukayama-Tomobe Y, Maeda S, Ohkubo T, Tanaka Y, Goto K, Yamaguchi I. Effects of medium-chain triglyceride (MCT) application to SHR on cardiac function, hypertrophy, and expression of endothelin-1 mRNA and other genes. J Cardiovasc Pharmacol. 44: S181-S185, 2004.

(6) Sugawara J, Maeda S, Otsuki T, Tanabe T, Ajisaka R, Matsuda M. Effects of nitric oxide synthase inhibitor on decrease in peripheral arterial stiffness with acute low intensity aerobic exercise. Am J Physiol Heart Circ Physiol. 287: H2666-H2669, 2004.

(7) Maeda S, Miyauchi T, Iemitsu M, Sugawara J, Nagata Y, Goto K. Resistance exercise training reduces plasma endothelin-1 concentration in healthy young humans. J Cardiovasc Pharmacol. 44: S443-S446, 2004.

(8) Maeda S, Tanabe T, Otsuki T, Sugawara J, Iemitsu M, Miyauchi T, Kuno S, Ajisaka R, Matsuda M. Moderate regular exercise increases basal production of nitric oxide in elderly women. Hypertens Res. 27: 947-953, 2004.

(9) Iemitsu M, Miyauchi T, Maeda S, Matsuda M, Goto K, Yamaguchi I. Time course alteration of endothelin-1 gene expression in the heart during exercise and 24-h postexercise periods in rats. J Cardiovasc Pharmacol. 44: S447-S450, 2004.

(10) 田辺匠,前田清司,菅原順,大槻毅,柿山哲治,横山典子,宮内卓,久野譜也,鯵坂隆一,松田光生. 中高齢者における身体活動が動脈系コンプライアンスおよび収縮期血圧に及ぼす影響. 体育学研究 49: 135-146, 2004.

(11) 菅原順,大槻毅,家光素行,永田可彦,田辺匠,本間覚,前田清司,鰺坂隆一,松田光生. Modelflow法による運動中の高齢者の心拍出量測定の妥当性. 日本臨床スポーツ医学会誌12: 516-520, 2004.

(12) 前田清司,家光素行. 遺伝子から見たスケール —運動と遺伝子—. 体育の科学 54: 185-190, 2004.

(13) 前田清司,松田光生. 運動・身体活動と血管内皮由来因子. 筑波大学体育科学系紀要 27: 1-7, 2004.

《2003年の論文》


(1) Miyauchi T, Maeda S, Iemitsu M, Kobayashi T, Kumagai Y, Yamaguchi I, Matsuda M. Exercise causes a tissue-specific change of NO production in the kidney and lung. J Appl Physiol. 94: 60-68, 2003.

(2) Maeda S, Tanabe T, Miyauchi T, Otsuki T, Sugawara J, Iemitsu M, Kuno S, Ajisaka R, Yamaguchi I, Matsuda M. Aerobic exercise training reduces plasma endothelin-1 concentration in older women. J Appl Physiol. 95: 336-341, 2003.

 

(3) Otsuki T, Sugawara J, Tanabe T, Maeda S, Ajisaka R, Matsuda M. Simple and noninvasive estimate of systemic arterial compliance by using peripheral arterial blood pressure waveform in elderly people. Int J Sport Health Sci. 1: 136-141, 2003.

(4) Horigome H, Miyauchi T, Takahashi-Igari M, Maeda S, Matsui A. Increased plasma level of endothelin-1 following percutaneous balloon dilatation of aortic coarctation in children. Eur J Pediatr. 162: 543-544, 2003.

(5) Otsuki T, Sugawara J, Tanabe T, Maeda S, Ajisaka R, Matsuda M. Noninvasive estimate of systemic arterial compliance by using peripheral arterial blood pressure waveform during light exercise in elderly people. Int J Sport Health Sci. 1: 142-147, 2003.

(6) Sugawara J, Otsuki T, Tanabe T, Maeda S, Kuno S, Ajisaka R, Matsuda M. The effects of low-intensity single-leg exercise on regional arterial stiffness. Jpn J Physiol. 53: 239-241, 2003.

(7) Sugawara J, Otsuki T, Tanabe T, Maeda S, Masuda K, Kuno S, Ajisaka R, Matsuda M. Statistical evaluation of endurance-training effects on systolic blood pressure in elderly people using a single-case design. Int J Sport Health Sci. 1: 148-153, 2003.

(8) Iemitsu M, Miyauchi T, Maeda S, Sakai S, Fujii N, Miyazaki H, Kakinuma Y, Matsuda M, Yamaguchi I. Difference in hypertensive and athletic hearts in gene expression of energy metabolic enzymes. Hypertens Res. 26: 829-837, 2003.

(9) Tanabe T, Maeda S, Miyauchi T, Iemitsu M, Takanashi M, Irukayama-Tomobe Y, Yokota T, Ohmori H, Matsuda M. Exercise training improves aging-induced decrease in eNOS expression of the aorta. Acta Physiol Scand. 178: 3-10, 2003.

(10) Sugawara J, Tanabe T, Miyachi M, Yamamoto K, Takahashi K, Iemitsu M, Otsuki T, Homma S, Maeda S, Ajisaka R, Matsuda M. Non-invasive assessment of cardiac output during exercise in healthy young humans: comparison between Modelflow method and Doppler echocardiography method. Acta Physiol Scand. 179: 361-366, 2003.

(11) Maeda S, Kurauchi M, Otsuki T, Tanabe T, Sugawara J, Ajisaka R, Matsuda M. Leg cycle training decreases upper limb arterial stiffness in elderly women. Int J Sport Health Sci. 1: 202-206, 2003.

(12) 田辺匠,前田清司,菅原順,大槻毅,宮内卓,久野譜也,鯵坂隆一,松田光生. 高齢者における日常の身体活動量が収縮期血圧に及ぼす影響 −動脈系コンプライアンスとの関連−. 体力科学 52 (Suppl): 167-176, 2003.

(13) 大槻毅,菅原順,田辺匠,前田清司,久野譜也,鰺坂隆一,松田光生. 中高齢女性の全身持久性体力に及ぼす動脈系コンプライアスの影響 —横断的および縦断的研究—. 日本臨床スポーツ医学会誌 11: 543-551, 2003.

(14) 横山典子,西嶋尚彦,前田清司,久野譜也,鯵坂隆一,松田光生. 中高年者における運動教室への参加が運動習慣化個人的要因に及ぼす影響 −個別実施運動プログラムと集団実施運動プログラムの比較−. 体力科学 52 (Suppl): 249-258, 2003.

(15) 家光素行,前田清司,宮内卓. 有酸素運動の継続は加齢による心臓・骨格筋の代謝能の低下を改善する. 健康維持増進とジェロンテクノロジー: 81-84, 2003.

《2002年の論文》


1) Maeda S, Miyauchi T, Iemitsu M, Tanabe T, Irukayama-Tomobe Y, Goto K, Yamaguchi I, Matsuda M. Involvement of endogenous endothelin-1 in exercise-induced redistribution of tissue blood flow: an endothelin receptor antagonist reduces the redistribution. Circulation. 106: 2188-2193, 2002.

(2) Maeda S, Takashi Miyauchi, Motoyuki Iemitsu, Takumi Tanabe, Tomoko Yokota, Katsutoshi Goto, Iwao Yamaguchi, Mitsuo Matsuda. Effects of exercise training on expression of endothelin-1 mRNA in the aorta of aged rats. Clin Sci (Lond). 103: 118-123, 2002.

(3) Iemitsu M, Miyauchi T, Maeda S, Tanabe T, Takanashi M, Irukayama-Tomobe Y, Sakai S, Ohmori H, Matsuda M, Yamaguchi I. Aging-induced decrease in the PPAR-α level in the heart is improved by exercise training. Am J Physiol Heart Circ Physiol. 283: H1750-H1760, 2002.

(4) Iemitsu M, Miyauchi T, Maeda S, Tanabe T, Irukayama-Tomobe Y, Goto K, Matsuda M, Yamaguchi I. Effects of aging and subsequent exercise training on gene expression of endothelin-1 in rat heart. Clin Sci (Lond). 103: 152-157, 2002.

(5) 柿山哲治,横山典子,前田清司,久野譜也,松田光生. 低強度運動の継続が中高齢者の大動脈伸展性に及ぼす影響. 健康医科学 17: 16-28, 2002.

(6) 横山典子,西嶋尚彦,前田清司,久野譜也,鯵坂隆一,松田光生. 運動教室への参加が中高年者の主観的幸福感に及ぼす影響. 体育測定評価研究 2: 11-19, 2002.

(7) 前田清司. 運動刺激と血管内皮. 体育の科学 52: 51-57, 2002.


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